UPDATE: Emergency services say five backpackers travelling in a car on the New England Hwy are lucky to be alive after the vehicle ploughed into a tree.
The crash occurred near Glen Aplin about 6.40am today.
All five have been taken to Stanthorpe Hospital in a serious but stable condition.
The northbound lane of the New England Highway was closed as fire and ambulance crews tried to free the passengers.
Stanthorpe police officer-in-charge Senior Sergeant Mark Ireland said emergency services arrived at the scene shortly after 7am.
"It is unknown who was behind the wheel at the time of the accident," he said.
Police will be visiting passengers at the hospital to determine the cause of the crash.
The northbound lane on the New England Hwyy remains closed as the Forensic Crash Unit investigates the incident.
7AM: Emergency services are on the scene of a horror traffic crash with reports motorists are trapped in the wreckage.
The incident is unfolding on the New England Hwy near Glen Aplin.
It was reported about 6.40am.
A Queensland Ambulance Service spokeswoman said a 25-year-old man had been transported by medical helicopter to Stanthorpe Hospital with serious back injuries while another 25-year-old man has been transported by ambulance by road to the same hospital in a stable condition with head and back injuries.
Two other people believed to be in their mid-20s sustained relatively minor injuries and will also be taken to Stanthorpe Hospital for treatment.
It is believed the car the injured were travelling in rolled on the highway.
Two people were trapped in the crash wreckage.
The New England Hwy was closed in both directions for two hours but has re-opened. However, traffic delays are expected to continue.
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